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目的：探讨自体肾移植后淋巴因素对移植肾的影响，为肾移植术是否需要吻合淋巴管提供参考。方法：实验动物为８只成年家犬，开腹，游离并切断左侧肾蒂，置于左髂窝，将肾动脉与左髂内动脉吻合，肾静脉与左髂总静脉吻合，但不吻合淋巴管，右肾作为对照，分别在术后第８、１２、２１天处死动物，用肉眼，光镜和透射电镜观察移植肾的变化。结果：肉眼观，左右肾的大小，颜色，质地无差别，但移植肾与周围组织广泛粘连；光镜：健侧肾皮质肾小管上皮细胞有水样变性，髓质内偶见少量的蛋白和细胞管型。患侧肾除见到与健侧类似的变化外，皮质内偶见脂肪变性，少数肾小球萎缩，部分肾小球代偿性肥大和集合管间质轻度纤维化；电镜：两侧肾小球无明显异常，实验侧近曲小管上皮细胞肿胀，微绒毛排列紊乱，胞浆内空泡增多，线粒体模糊，溶酶体增多，远曲小管和集合管部分上皮细胞坏死。结论：肾移植时可暂不考虑吻合淋巴管
Objective: To investigate the effect of lymphatic factor on renal graft after autologous renal transplantation, and to provide reference for the need of anastomosis of lymphatic vessel in renal transplantation. Methods: The experimental animals were 8 adult dogs. The left renal pedicle was excised and cut off. The left renal pedicle was placed in the left iliac fossa. The renal artery was anastomosed with the left internal iliac artery. The renal vein was anastomosed with the left common iliac vein, Lymphatic vessels and right kidney were used as controls. Animals were sacrificed on the 8th, 12th and 21st day after operation. The changes of the graft kidney were observed with naked eye, light microscope and transmission electron microscope. Results: The naked eye, the size of the left and right kidneys, color, texture, no difference, but the graft and surrounding tissue extensive adhesions; light microscope: contralateral renal cortical tubular epithelial cells have watery degeneration, occasional few medullary protein and Cell tube. Ipsilateral kidney in addition to see and similar changes in the contralateral, the cortex, occasionally steatosis, a small number of glomerular atrophy, compensatory partial glomerular compensatory hypertrophy and interstitial mesenchymal fibrosis; electron microscopy: both sides of the kidney There was no obvious abnormality in the pellet. The tubule epithelial cells in the experimental side were swollen, the arrangement of microvilli was disordered, the cytoplasm vacuolus was increased, the mitochondria were blurred, the lysosomes were increased, and the distal convoluted tubules and part of the collecting duct were necrosis. Conclusion: Renal transplantation can temporarily consider anastomosis of lymphatic vessels