B细胞受体(BCR)复合物及其介导的下游信号途径在正常B细胞及多种B细胞肿瘤中发挥着着至关重要的作用,调控BCR途径关键分子的活性可以选择性地促进或抑制特定B细胞扩增。近年来,针对此通路上不同成分的靶向药物在B细胞肿瘤的临床试验中取得良好的治疗效果,如脾酪氨酸激酶(Syk)抑制剂、PI3K抑制剂、Bruton’s酪氨酸激酶(Btk)抑制剂等。本文就BCR信号通路在B细胞肿瘤中的作用及针对该途径的靶向药物进 B cell receptor (BCR) complexes and their downstream signaling pathways play a crucial role in normal B cells and many B cell tumors, and the modulation of the activity of key molecules of the BCR pathway can selectively promote Inhibit specific B cell expansion. In recent years, targeted drugs targeting different pathways have achieved good therapeutic effects in clinical trials of B cell tumors such as Syk inhibitor, PI3K inhibitor, Bruton’s tyrosine kinase (Btk ) Inhibitors and the like. In this paper, the role of BCR signaling in B cell tumors and the targeting of drugs to this pathway