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本文分别对妊娠12～14天(中孕)和18～20天(晚孕)SD大鼠肝微粒体单加氧酶系统的活性进行了研究,结果表明:与非妊娠对照组相比,中孕大鼠肝微粒体细胞色素P-450含量,b5含量及细胞色素C还原酶活性分别下降50％(P<0.01)、75％(P<0.01)和38％(P<0.01),晚孕者分别下降38％(P<0.01)、45％(P<0.01)和35％(P<0.01)。中孕、晚孕大鼠肝微粒体苯胺羟化酶(ANH)活性分别下降75％和76％(P<0.01),其活性的降低与P-450含量及细胞色素C还原酶活性的减少呈高度直线正相关(r=0.851,P<0.01;r=0.884,P<0.01)。妊娠各期间肝微粒体氨基比林N-脱甲基酶(AMD)活性无显著改变。
In this study, the activities of the monooxygenase system of liver microsomes in SD rats at 12 to 14 days (middle pregnancy) and 18 to 20 days (late pregnancy) were studied. The results showed that: compared with non-pregnant controls, The content of cytochrome P-450, b5 and cytochrome C reductase activity in liver microsomes of pregnant rats decreased by 50% (P<0.01), 75% (P<0.01), and 38% (P<0.01), respectively. They were decreased by 38% (P<0.01), 45% (P<0.01), and 35% (P<0.01). Aniline hydroxylase (ANH) activity in hepatic microsomes decreased by 75% and 76% in rats of second and third trimester, respectively (P<0.01). The decrease in activity and the decrease of P-450 content and cytochrome C reductase activity were observed. The height was positively correlated (r=0.851, P<0.01; r=0.884, P<0.01). There was no significant change in the activity of aminopyrine N-demethylase (AMD) in liver microsomes during each period of pregnancy.