1917年Schick提出肾炎的基本成因是免疫反应。60年代发现许多类型的肾小球肾炎病变同时伴有多种免疫球蛋白、补体和纤维粘连蛋白抗原在肾小球不同部位、肾小管和间质沉积。90年代末已公认肾小球肾炎的起始原因是免疫反应所产生的肾小球内免疫复合物。但免疫复合物并不一定致病,还需要 In 1917 Schick proposed that the basic cause of nephritis is the immune response. 60 years found that many types of glomerulonephritis lesions accompanied by a variety of immunoglobulin, complement and fibronectin antigen in different parts of the glomerulus, tubules and interstitial deposition. The beginning of the late 90s has been recognized as the initial cause of glomerulonephritis caused by the immune response glomerular immune complexes. However, immune complexes are not necessarily pathogenic, but also need