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目的探讨中国江苏汉族儿童L-ficolin基因Thr236Met位点多态性与反复呼吸道感染的相关性。方法采用碱基淬灭探针技术检测104例反复呼吸道感染患儿及214例对照组儿童L-ficolin基因Thr236Met位点多态性。结果L-ficolin基因Thr236Met多态性基因型和等位基因频率分布在反复呼吸道感染组和对照组比较差异无统计学意义(P>0.05)。结论中国江苏汉族儿童反复呼吸道感染的发病与L-ficolin基因Thr236Met位点多态性没有关联。
Objective To investigate the association of Thr236Met polymorphism of L-ficolin gene with recurrent respiratory tract infection in Han children from Jiangsu, China. Methods The base-quencher probe technique was used to detect Thr236Met polymorphism of L-ficolin gene in 104 children with recurrent respiratory tract infection and 214 control children. Results There was no significant difference in Thr236Met polymorphism genotypes and allele frequency between the recurrent respiratory tract infection group and the control group (P> 0.05). Conclusions The incidence of recurrent respiratory tract infection in Han children of Jiangsu province in China is unrelated to the Thr236Met polymorphism of L-ficolin gene.