纤维蛋白原和α_2-血浆酶抑制物(α_2-PI)的沉积,是 IgA 肾病(IgAN)患者肾小球损害加重的原因之一。作者在既往报道中指出,连续尿激酶(UK)治疗能改善 IgAN 患者的肾脏损害。本文旨在研究 IgAN患者应用 UK 治疗的长期作用。57例 IgAN 患者,男44、女13例,平均年龄37岁.血肌酐(Scr)<2.0mg/dl。肾活检标本均作光镜、电镜和免疫荧光检查。本文选择中度和进行性肾 The deposition of fibrinogen and α_2-plasma enzyme inhibitor (α_2-PI) is one of the causes of glomerular damage in patients with IgA nephropathy (IgAN). The authors in previous reports pointed out that continuous urokinase (UK) treatment can improve renal damage IgAN patients. This article aims to investigate the long-term effects of UK therapy in patients with IgAN. 57 cases of IgAN patients, 44 males and 13 females, mean age 37 years, serum creatinine (Scr) <2.0mg / dl. Renal biopsy specimens were light microscope, electron microscopy and immunofluorescence. This article chooses moderate and progressive kidney