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本文介绍血浆交换(plasma exchange,PE)治疗8例四种免疫性疾病,应用PE前后测定外周血T细胞集落数、单克隆抗体(monoclone antibody,McAb)对T细胞亚群的标记和循环免疫复合物(circulating immune complex,CIC)的改变及其相互间关系的比较,探索PE产生疗效的机理和检测疗效的指标。实验资料提示,PE后机体内有害抗体、CIC的清除、细胞免疫功能的词正等均属产生疗效的机理,系综合性的作用。检测疗效的指标有T细胞集落数(TL-CFU)、CIC值和T_H与T_S比值的恢复。PE后CIC下降、T_H上升,与PE前相比其P值均<0.01。而换浆后含有病人血浆及血清成份的T细胞集落数的恢复正常,对检测PE后的疗效尤为敏感、确切。
This article describes the plasma exchange (plasma exchange, PE) treatment of eight cases of four immune diseases, determination of peripheral blood T cell colony counts before and after the use of PE, monoclonal antibody (monoclonal antibody) (monoclonal antibody) on T cell subsets and immune complex (CIC) changes and their mutual relationship between the comparison of PE to explore the mechanism of efficacy and detection of indicators of efficacy. Experimental data suggest that PE after the body harmful antibodies, CIC removal, the word is the cellular immune function is to produce the mechanism of efficacy, the Department of a comprehensive role. The indicators of efficacy were T-cell colony count (TL-CFU), CIC value and T_H and T_S ratio recovery. After PE, CIC decreased and T_H increased, P <0.01 compared with that before PE. However, the number of T-cell colonies that contained the plasma and serum components of the patient plasma returned to normal after the plasmapheresis, which is particularly sensitive and exact to the effect of detecting PE.