论文部分内容阅读
目的探讨雌激素靶器官肿瘤雌激素受体(estrogen receptor,ER)表达强度与术后下肢深静脉血栓形成(deep vein thrombosis,DVT)的关系。方法选取2013年5月—2016年5月接受手术治疗的子宫内膜癌患者20例(观察1组)、乳腺癌患者20例(观察2组),均于术后2周内出现下肢DVT。另选取年龄相匹配而未发生DVT的子宫内膜癌(对照1组)及乳腺癌患者(对照2组)各20例。收集各组病历资料,包括术前血清雌二醇(E_2)、术前BMI、手术时间、制动时间、术中失血量、ER蛋白阳性细胞百分比。免疫组化法检测肿瘤组织中ER蛋白表达。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组与对应的对照组术前血清E2、手术时间、制动时间、术中出血量比较差异无统计学意义(均P>0.05)。单因素分析显示,雌激素靶器官肿瘤术后下肢DVT的影响因素为手术时间、制动时间、术中出血量、ER表达强度和BMI(均P<0.05)。结论雌激素靶器官肿瘤组织ER呈高表达,ER是下肢DVT的危险因素。
Objective To investigate the relationship between the estrogen receptor (ER) expression and the postoperative deep vein thrombosis (DVT) in estrogen target organs. Methods Twenty patients with endometrial cancer undergoing surgery (group 1) and 20 patients with breast cancer (group 2) underwent surgery from May 2013 to May 2016. All patients underwent DVT in the lower limb within 2 weeks after operation. Another 20 patients with endometrial cancer (control group 1) and breast cancer patients (control group 2) matched for age without DVT. The records of each group were collected, including preoperative serum estradiol (E2), preoperative BMI, operation time, braking time, intraoperative blood loss and ER protein positive cell percentage. The expression of ER protein in tumor tissue was detected by immunohistochemistry. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results There was no significant difference in preoperative serum E2, operation time, braking time and intraoperative blood loss between the observation group and the corresponding control group (all P> 0.05). Univariate analysis showed that the influencing factors of DVT of lower extremity after esophageal tumor were operative time, braking time, intraoperative blood loss, ER expression intensity and BMI (all P <0.05). Conclusion ER is highly expressed in estrogen target organs and ER is a risk factor for lower extremity DVT.