论文部分内容阅读
肌侵蛋白是12kDa的锚蛋白重复序列(ANK)蛋白,是最小的(ANK)2重复蛋白,ANK结构域使其能介导蛋白之间以及蛋白与核酸之间的相互作用。肌侵蛋白在哺乳动物的组织中广泛表达并能刺激心肌细胞的生长和心肌蛋白的合成。它最初是在肥厚和患有心肌病的心脏中被鉴定,起始心脏肥厚的过程,并最终导致心力衰竭(心衰)。近来的研究表明核转录因子-kappaB(NF-κB)参与心脏重塑和心衰的病理过程,而肌侵蛋白通过与NF-κB蛋白相互作用活化NF-κB信号途径激活心脏肥厚基因的表达。
The haptoglobin is an 12kDa ankyrin repeat (ANK) protein that is the smallest (ANK) 2 repeat protein that enables it to mediate the interaction between proteins and between proteins and nucleic acids. Haptoglobin is widely expressed in mammalian tissues and stimulates cardiomyocyte growth and myocardial protein synthesis. It was initially identified in hypertrophic and cardiomyopathic hearts, initiating cardiac hypertrophy and eventually leading to heart failure (heart failure). Recent studies have shown that the nuclear transcription factor-kappaB (NF-κB) is involved in the pathophysiology of cardiac remodeling and heart failure, whereas the expression of cardiac hypertrophy gene activates NF-κB signaling through the interaction with NF-κB.