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本文基于配体交换的机理,研究了以脯氨酸手性离子液体作为手性配体拆分扁桃酸(MA)对映体的方法及热力学过程。详细考察了手性离子液体的烷基链长、铜离子的浓度、离子液体的浓度和pH等因素对MA对映体分离的影响。研究发现,不同烷基链长的手性离子液体中,以1-丁基-3-甲基咪唑L-脯氨酸为配体时,MA对映体的拆分效果最好;随着铜离子浓度的增加,MA对映体的保留时间和分离度先增大再减小;而随着1-丁基-3-甲基咪唑L-脯氨酸离子液体的浓度和流动相pH的增大,保留时间和分离度均增大。本文还测定了拆分过程中的一些热力学参数,结果表明,MA对映体的拆分过程是一个焓控的过程,L-MA较D-MA与固定相有更强的相互作用,保留时间更长。
Based on the mechanism of ligand exchange, the method and thermodynamic process of enantiomer separation of mandelic acid (MA) with proline chiral ionic liquid as chiral ligand were studied. The effects of alkyl chain length, copper ion concentration, ionic liquid concentration and pH on the enantiomeric separation of MA were investigated in detail. The results showed that the resolution of MA enantiomers was the best when using 1-butyl-3-methylimidazolium L-proline as ligand in chiral ionic liquids with different alkyl chains. With the increase of ion concentration, the retention time and resolution of MA enantiomer firstly increased and then decreased. With the increase of the concentration of 1-butyl-3-methylimidazolium L-proline ionic liquid and the increase of mobile phase pH Large, retention time and resolution are increased. Some thermodynamic parameters in the resolution process were also determined. The results show that the resolution of MA enantiomers is a process of enthalpy control. L-MA has a stronger interaction with D-MA than the stationary phase. The retention time Longer.