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目的:观察中西医(中南大学湘雅医学院附属肿瘤医院)结合方法治疗中晚期胃癌的客观疗效、症状改善、生活质量、生存率等方面情况。方法:观察中晚期胃癌48例,随机分为治疗组24例,对照组24例,治疗组采用化疗加中药,对照组单纯化疗。结果:中药组在症状改善、生活质量、生存率方面均优于对照组(P<0.05),客观疗效两组比较无明显差异(P>0.05)。两组近期毒性反应中恶心呕吐、白细胞减少、粒细胞减少、血小板减少中药组优于对照组,有统计学意义(P<0.05);腹泻、口腔黏膜反应、肝功能损害两组反应均较轻,无明显差异(P>0.05)。结论:中西医结合治疗能改善患者症状,减轻化疗副反应,提高生活质量,延长患者生存期。
Objective: To observe the objective curative effect, symptom improvement, quality of life, survival rate and other aspects of the combination of Chinese and Western medicine (Cancer Hospital of Xiangya School of Medicine, Central South University) in the treatment of advanced gastric cancer. Methods: Forty-eight cases with advanced gastric cancer were randomly divided into treatment group (n = 24) and control group (n = 24). The treatment group was treated with chemotherapy plus Chinese herbs and the control group with chemotherapy alone. Results: The TCM group was better than the control group in symptom improvement, quality of life and survival rate (P <0.05). There was no significant difference in objective curative effect between the two groups (P> 0.05). The two groups of recent toxic reactions nausea and vomiting, leukopenia, neutropenia, thrombocytopenia in the traditional Chinese medicine group was better than the control group, with statistical significance (P <0.05); diarrhea, oral mucosal reactions, liver dysfunction were mild in both groups , No significant difference (P> 0.05). Conclusion: Integrative Chinese and Western medicine can improve the symptoms of patients, reduce chemotherapy side effects, improve quality of life and prolong survival.