测定罗望子胶的急性毒性,并选用3种体内和体外的短期测试系统,对其致突变进行试验。实验结果表明,罗望子胶对雌,雄性大鼠、小鼠经口 LD_(50)分别为9 260 mg/kg 和大于10 000mg/kg,属于实际无毒。在 Ames 试验中。未呈现致突变性。在体内试验中,未引起小鼠骨髓嗜多染红细胞微核率和小鼠精子畸变率的增加,在3项致变试验中,罗望子胶未呈现致突变活性。 The acute toxicity of tamarind gum was determined, and three kinds of in vivo and in vitro short-term test systems were selected and tested for mutagenesis. The experimental results showed that the oral LD_(50) of tamarind gum was 9 260 mg/kg and greater than 10 000 mg/kg in female and male rats respectively. In the Ames test. Does not exhibit mutagenicity. In the in vivo test, there was no increase in the micronucleus rate of mouse polymorphonuclear red blood cells and the sperm aberration rate in mice. In the three mutation assays, tamarind gum showed no mutagenic activity.