论文部分内容阅读
目的总结和探讨肝移植术后乙肝复发的预防与处理。方法回顾性分析253例乙肝相关性肝病行肝移植术患者乙肝防治方法、术后乙肝复发的处理。结果术后乙肝复发者7例,复发率2.76%。复发后分别采用加大乙肝免疫球蛋白(HB IG)剂量、改用恩替卡韦、加用贺维力等措施,2例HBsAg经治疗后转阴,2例HBsAg明显下降,总有效率57%。结论肝移植术后HB IG+拉米夫丁能有效预防肝移植术后乙肝复发,HB IG、恩替卡韦、贺维力能不同程度控制肝移植术后乙肝复发。
Objective To summarize and explore the prevention and treatment of hepatitis B recurrence after liver transplantation. Methods A retrospective analysis of 253 cases of hepatitis B-related liver disease patients undergoing liver transplantation in prevention and treatment of hepatitis B, hepatitis B recurrence after treatment. Results Postoperative hepatitis B recurrence in 7 cases, the recurrence rate was 2.76%. After the relapse, the HBIG dose was increased, entecavir was used, and He Weili was added. Two cases of HBsAg were negative after treatment and two cases of HBsAg decreased obviously with a total effective rate of 57%. Conclusions HBIG + lamivudine can effectively prevent the recurrence of hepatitis B after liver transplantation. HBIG, entecavir and Heverin can control the recurrence of hepatitis B after liver transplantation.