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目的系统评价陷窝蛋白-1(Caveolin-1)在胃癌组织的表达及与其临床病理特征的相关性。方法检索万方、维普、中国知网、Pub Med等数据库,查找从2000年1月—2017年5月,国内外公开发表的关于Caveolin-1蛋白表达与胃癌及其临床病理特征相关性的病例对照研究,筛选文献、提取资料和对纳入研究进行方法学质量评价,采用Rev Man 5.3软件对纳入研究进行Meta分析。结果经筛检共纳入12个病例对照研究,共包括胃癌组1 380例,其中Caveolin-1表达阳性286例;非癌胃黏膜组295例,其中Caveolin-1表达阳性264例;胃黏膜癌前病变组238例,其中Caveolin-1表达阳性180例。Meta分析结果显示:Caveolin-1在非癌胃黏膜组织与胃癌组织[比值比(odds ratio,OR)=23.74,95%置信区间(confidence interval,CI)15.19,37.11,P<0.000 01]、胃黏膜组织癌前病变与胃癌组织[OR=6.58,95%CI(4.52,9.58),P<0.000 01]、非癌胃黏膜组织与胃黏膜癌前病变[OR=2.88,95%CI(1.58,5.25),P=0.000 6]表达的比较,差异均有统计学意义;Caveolin-1与胃癌不同临床病理特征相关性分析发现:Caveolin-1蛋白在低分化型与中、高分化型胃癌组织[OR=0.48,95%CI(0.33,0.70),P=0.000 1]、不伴淋巴结转移组与伴淋巴结转移组织[OR=3.19,95%CI(1.77,5.74),P=0.000 1]表达的比较,差异均有统计学意义。结论 Caveolin-1在胃癌组织中表达缺失,并且与胃癌临床病理特征密切相关,但由于受纳入研究数量和质量的限制,对于Caveolin-1能否作为胃癌的肿瘤标志物尚需进一步开展深入研究加以验证。
Objective To evaluate the expression of Caveolin-1 in gastric carcinoma and its relationship with clinicopathological features. Methods The databases of Wanfang, Weipu, CNKI, Pub Med and other databases were searched from January 2000 to May 2017, and the domestic and international published cases about the correlation between Caveolin-1 protein expression and gastric cancer and their clinicopathological features Control studies, screening of literature, data extraction, and methodological quality assessment of included studies were conducted using meta-analysis of the included studies using RevMan 5.3 software. Results A total of 12 case-control studies were included in the study, including 1 380 cases of gastric cancer group, including 286 cases of Caveolin-1 positive expression, 295 cases of non-cancerous gastric mucosa group, 264 cases of which were positive for Caveolin-1, The lesions of 238 cases, including Caveolin-1-positive 180 cases. The results of Meta analysis showed that Caveolin-1 had no significant difference between non-cancerous gastric mucosa and gastric cancer tissue [odds ratio (OR) = 23.74, 95% confidence interval (CI) 15.19, 37.11, P <0.000 01] Mucosal precancerous lesions and gastric cancer (OR = 2. 58, 95% CI: 4.52, 9.58, P <0.000 01) 5.25), P = 0.0006], the differences were statistically significant; Caveolin-1 and gastric cancer different clinicopathological characteristics of the correlation analysis found that: Caveolin-1 protein in poorly differentiated and moderately differentiated gastric cancer [ OR = 0.48, 95% CI (0.33, 0.70), P = 0.0001], with no lymph node metastasis and lymph node metastasis [OR = 3.19,95% CI (1.77,5.74), P = 0.0001] Comparison, the differences were statistically significant. Conclusions The expression of Caveolin-1 is absent in gastric carcinoma and closely related to the clinicopathological features of gastric carcinoma. However, due to the limitation of the quantity and quality of the study, Caveolin-1 needs to be further studied as a tumor marker for gastric cancer verification.