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目的分析比较来曲唑(LE)、人绝经期促性腺激素(HMG)以及LE联合HMG三种促排卵方案的临床效果。方法将306例不孕不育患者共382个周期分为三组。A组予LE、B组予HMG、C组予LE联合HMG促排卵治疗。分析比较三组促排卵方案的临床效果。结果 HCG日子宫内膜厚度和卵泡成熟时间三组比较差异均无统计学意义(均P>0.05),HCG日卵泡直径≥17 mm卵泡数A组与B、C两组相比较差异均有统计学意义(均P<0.05)。为防止发生卵巢过度刺激(OHSS)而放弃注射HCG患者数B组明显高于A、C组(均P<0.05)。因无反应(在月经周期第20日B超仍未监测到优势卵泡)而取消患者数,A组明显高于B、C组(均P<0.05)。三组的临床妊娠率、流产率、未破裂卵泡黄素化综合症(LUFS)发生率差异均无统计学意义(均P>0.05)。A、B、C组排卵率分别为76.3%、72.2%、95.5%,临床妊娠率分别为13.0%、13.5%、30.2%;FSH/LH>2者共87例排卵率及妊娠率显示C组促排卵治疗后排卵率及临床妊娠率均较A组和B组高(均P<0.05)。结论 LE联合HMG在促排卵治疗方面有明显优势,不失为一种方便、可行的方法。
Objective To compare and analyze the clinical effects of levodopa (LE), human menopausal gonadotrophin (HMG) and LE combined with HMG on ovulation induction. Methods A total of 382 cycles of 306 infertility patients were divided into three groups. Group A to LE, group B to HMG, group C to LE combined with HMG ovulation induction therapy. The clinical effects of three ovulation induction programs were analyzed and compared. Results There was no significant difference in endometrial thickness and follicular maturation time between the HCG group and the control group (all P> 0.05). There were statistically significant differences between the two groups Significance (both P <0.05). In order to prevent ovarian hyperstimulation (OHSS) and give up the number of HCG injection group B was significantly higher than the A, C group (P <0.05). The number of patients was canceled because of no reaction (no superior follicles were detected on the 20th day of the menstrual cycle), which was significantly higher in group A than in groups B and C (all P <0.05). There was no significant difference in clinical pregnancy rate, miscarriage rate and luteinizing syndrome (LUFS) between the three groups (all P> 0.05). The ovulation rates in groups A, B and C were 76.3%, 72.2% and 95.5%, respectively, and the clinical pregnancy rates were 13.0%, 13.5% and 30.2% respectively. There were 87 cases of ovulation rate and pregnancy rate in FSH / LH> The ovulation rate and clinical pregnancy rate after ovulation induction were higher than those in group A and B (all P <0.05). Conclusion LE combined with HMG in ovulation induction treatment has obvious advantages, after all, a convenient and feasible method.