论文部分内容阅读
目的通过优化手段筛选最佳处方,制备长春西汀长循环脂质体。方法采用薄膜分散法制备长循环脂质体,分别以磷脂质量浓度(1ρ)、Tween80质量浓度(ρ2)、磷脂-药质量比(ms∶md)为考察对象,以包封率(Y1)、载药量(Y2)和粒径(d)为评价指标,利用三因素三水平Box-Behnken效应面设计法筛选长循环脂质体的最佳处方;透射电子显微镜考察其形态与粒径。结果长循环脂质体的包封率为85.9%;载药量18.5 mg.g-1;粒径为213.4 nm,与理论值偏差均小于10%。结论长春西汀长循环脂质体采用Box-Behnken实验设计法优化是可行的。
OBJECTIVE To screen the optimal formulation by optimization and to prepare vinpocetine long-circulating liposomes. Methods The liposomes were prepared by membrane dispersion method. The concentrations of phospholipid (1ρ), Tween80 (ρ2), phospholipid - drug mass ratio (ms: md) Drug loading (Y2) and particle size (d) were evaluated. The best prescription of long-circulating liposomes was screened by the three-factor and three-level Box-Behnken effect surface design method. Transmission electron microscope was used to investigate the morphology and particle size. Results The encapsulation efficiency of long-circulating liposomes was 85.9%. The drug loading was 18.5 mg.g-1. The particle size was 213.4 nm, which was less than 10% of the theoretical value. Conclusion Vinpocetine long circulating liposomes using Box-Behnken experimental design method is feasible.