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为探讨治疗中晚期肝癌的理想方法，扩大和发展光动力疗法，自１９９４年６月起，我们应用光动力疗法（ＰＤＴ）治疗中晚期肝癌３０例，其中肝细胞癌２８例、腺癌２例。肿瘤直径７～１０ｃｍ的１３例、１０ｃｍ以上至１６ｃｍ的１７例。伴肺转移５例、骨转移５例、门静脉或腔静脉浸润４例。首次治疗１９例、其他方法治疗无效或复发者１１例。本研究采用氩激光泵浦染料激光器系统，获得６３０ｎｍ波长的连续波治疗光。光敏剂选用血卟啉衍生物（ＨｐＤ）。治疗时通过Ｂ超引导经皮肝穿，将光纤导入肿瘤组织中布点照射。治疗后未见肝功能明显损伤，未出现肝穿出血、腹膜炎等严重并发症，没有一个月内病情恶化者。有１４例患者只作一次治疗，其中５例出院后失访；另９例肿瘤部分缓解率为２２％。１６例患者接受二、三次治疗，肿瘤部分缓解率达到６２％。随访病例中有８例已存活１年以上。
To explore the ideal method for the treatment of advanced hepatocellular carcinoma, expand and develop photodynamic therapy. Since June 1994, we applied photodynamic therapy (PDT) to treat 30 cases of advanced liver cancer, including 28 cases of hepatocellular carcinoma and 2 cases of adenocarcinoma. . There were 13 cases with a tumor diameter of 7 to 10 cm and 17 cases of 10 cm to 16 cm. There were 5 cases with pulmonary metastases, 5 cases with bone metastases, and 4 cases with portal vein or vena cava infiltration. The first treatment of 19 cases, other methods of treatment failure or relapse in 11 cases. In this study, an argon laser-pumped dye laser system was used to obtain CW-wavelength continuous-wave therapeutic light. The photosensitizer used hematoporphyrin derivative (HpD). During the treatment, percutaneous transhepatic perforation was performed through B-ultrasound, and the fiber was introduced into the tumor tissue to illuminate the site. After the treatment, no obvious liver function damage was observed, no serious complications such as hepatic bleeding, peritonitis, etc. were observed, and none of the patients deteriorated within one month. There were 14 patients treated only once, of which 5 were lost after discharge; the other 9 patients had a partial response rate of 22%. Sixteen patients received two or three treatments and the partial remission rate reached 62%. Eight of the follow-up cases had survived for more than one year.