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目的探讨三维适形放射治疗中晚期胰腺癌的疗效及毒性。方法对30例中晚期胰腺癌患者采用三维适形放射治疗。单次剂量在1.8~2 Gy,每周照射5次,总剂量50~60 Gy/5~6周。结果上腹及腰背部疼痛完全缓解率70.0%(21/30);退黄率63.3%(19/30)。放疗结束后1~3个月行CT复查,瘤体CR率26.6%(8/30),PR率为46.6%(14/30),总有效率为73.2%(22/30),中位生存期13个月,1年生存率55.0%。治疗后出现血象下降Ⅰ~Ⅱ级者占63.3%(19/30),Ⅲ级者6.6%(2/30),Ⅰ~Ⅱ级恶心、呕吐60.0%(18/30)。结论三维适形放射治疗能够改善中晚期胰腺癌患者的生活质量,提高生存率。
Objective To investigate the efficacy and toxicity of three-dimensional conformal radiotherapy for advanced pancreatic cancer. Methods Thirty patients with advanced pancreatic cancer were treated with three-dimensional conformal radiotherapy. A single dose of 1.8 ~ 2 Gy, weekly irradiation 5 times, a total dose of 50 ~ 60 Gy / 5 ~ 6 weeks. Results The complete remission rate of upper and lower back pain was 70.0% (21/30) and the rate of yellowing was 63.3% (19/30). The CT rate was 26.6% (8/30), the PR rate was 46.6% (14/30) and the total effective rate was 73.2% (22/30). The median survival Period of 13 months, 1-year survival rate of 55.0%. After the treatment, blood descending grade Ⅰ ~ Ⅱ accounted for 63.3% (19/30), grade Ⅲ 6.6% (2/30), grade Ⅰ ~ Ⅱ nausea and vomiting 60.0% (18/30). Conclusion Three-dimensional conformal radiotherapy can improve the quality of life and improve the survival rate of patients with advanced pancreatic cancer.