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目的比较米非司酮配伍不同剂量米索前列醇终止12~25周妊娠效果。方法将妊娠12~25周自愿要求终止妊娠的健康妇女100例,随机分为两组,米非司酮200mg顿服,36h后阴道内置米索前列醇400μg(组Ⅰ)或600μg(组Ⅱ),若24h未见妊娠物排出则重复给药1次。第1次用米索前列醇后48h内妊娠物排出为成功。结果两组引流产成功率分别为94%和100%,引流产时间分别为9.06±8.25h和6.70±4.82h,两组比较均无显著性差异(P>0·05)。产时阴道出血量、胎盘胎膜残留率、呕吐、腹泻、头痛、头晕等副反应两组间差异无显著性意义,组Ⅰ发热的发生率明显低于组Ⅱ(P<0·05)。结论口服米非司酮200mg配伍米索前列醇400μg及600μg用于终止12~25周妊娠,引产效果均比较满意,但400μg组发生副反应更低,而600μg组引流产时间较短,米索前列醇的最佳用药量还需进一步探讨。
Objective To compare the effect of mifepristone and different doses of misoprostol to terminate the pregnancy of 12 ~ 25 weeks. Methods A total of 100 healthy pregnant women who were asked to terminate their pregnancy voluntarily from 12 weeks to 25 weeks of gestation were randomly divided into two groups: 200 mg mifepristone daily, 400 μg misoprostol (group Ⅰ) or 600 μg (group Ⅱ) , If no pregnancy was discharged 24 hours repeated administration 1 times. The first pregnancy with misoprostol within 48h after discharge as a success. Results The successful rates of drainage in both groups were 94% and 100% respectively, and the drainage time was 9.06 ± 8.25h and 6.70 ± 4.82h respectively. There was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups in the incidence of vaginal bleeding during labor, the residual rate of placental membranes, vomiting, diarrhea, headache and dizziness. The incidence of fever in group Ⅰ was significantly lower than that in group Ⅱ (P <0.05). Conclusions Oral mifepristone 200mg with misoprostol 400μg and 600μg for terminating 12 to 25 weeks of pregnancy, induction of labor are more satisfactory, but 400μg group had lower side effects, and 600μg group drainage time is shorter, misoprostol The optimal dosage of prostatol need to be further explored.