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目的:探讨类风湿因子阳性与阴性类风湿关节炎(rheumatoid arthritis,RA)患者外周血中辅助T细胞(Th17)及相关细胞因子白介素17(interleukin,IL-17),白介素6(interleukin,IL-6)表达的差异。方法:收集RA患者51例,根据RF测定分为RF+、RF-组,健康查体者(对照组)20例,采用流式细胞术检测受检者外周血单个核细胞(PBMC)的Th17细胞的百分率;以酶联免疫吸附法(ELISA)检测受检者血浆中IL-17,IL-6的水平。结果:RA患者CD4+IL-17+T细胞,IL-17、IL-6水平均高于对照组,RF因子阳性与阴性RA患者之间CD4+IL-17+T细胞,IL-17、IL-6表达水平均存在差异有统计学意义。结论:在RA中不同RF型免疫反应和炎症表达的不同,可能与Th17及相关细胞因子表达差异有关。
Objective: To investigate the relationship between Th17 and interleukin (IL-17), interleukin (IL-17) and interleukin-6 (IL-17) in peripheral blood of patients with rheumatoid arthritis (RA) 6) Differences in expression. Methods: Fifty-one patients with RA were enrolled and divided into RF +, RF- and healthy subjects (control group) according to RF. Twenty-seven patients with RA were examined by flow cytometry for Th17 cells in peripheral blood mononuclear cells (PBMCs) The percentage of IL-17 and IL-6 in the plasma of the subjects were detected by enzyme-linked immunosorbent assay (ELISA). Results: The levels of CD4 + IL-17 + T cells, IL-17 and IL-6 in RA patients were significantly higher than those in control subjects. The levels of CD4 + IL-17 + T cells, IL- 17, IL -6 expression levels were statistically significant differences. CONCLUSION: The differences in the expression of different RF-type immune responses and inflammation in RA may be related to the differences in the expression of Th17 and related cytokines.