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目的 研究幼龄厌食大鼠中枢及外周八肽胆囊收缩素 (CCK - 8)的含量变化以及运脾方药对它们的调节作用。方法模拟小儿厌食症的主要病因制作幼龄厌食大鼠模型 ,用儿宝颗粒治疗 ,运用放免检测技术测定动物下丘脑及外周血中CCK -8的含量。结果 模型动物下丘脑和血浆CCK - 8浓度分别为 (12 2 .5 7± 31.79)pmoL/ g和 (5 0 6 .88± 113.32 ) pg/mL ,显著高于正常组 (89.15± 17.94) pmoL/g(P <0 .0 5 )和 (2 5 3.76± 6 5 .0 9) pg/mL(P <0 .0 5 ) ;摄食量明显下降 ,持续 3周以上 ;大小剂量治疗组摄食量均增加 ,下丘脑及血浆CCK - 8含量恢复正常。结论 幼龄厌食大鼠模型中枢和外周CCK - 8浓度增高 ,运脾方药对此有明显的抑制作用。
Objective To study the changes of CCK-8 concentration in the central and peripheral octapeptides of young rats with anorexia and the regulatory effects of Yunpi Recipe on them. Methods To simulate the main causes of anorexia in children and to establish a rat model of anorexia in the young, and to treat it with Erbao Granules. Radioimmunoassay was used to measure the content of CCK-8 in hypothalamus and peripheral blood of animals. Results The hypothalamic and plasma CCK-8 concentrations in the model animals were (12 2 .57 ± 31.79) pmoL/g and (5 0 6 .88± 113.32) pg/mL, respectively, which were significantly higher than those in the normal group (89.15± 17.94). /g (P <0.05) and (2 5 3.76 ± 65.09) pg/mL (P <0.05); Food intake decreased significantly for more than 3 weeks; Food intake in large and small dose groups Both increased, and the content of CCK-8 in the hypothalamus and plasma returned to normal. Conclusion The concentration of CCK-8 in the central and peripheral regions of the young rats with anorexia can be increased, and the herbs for transporting spleen have obvious inhibitory effect.