论文部分内容阅读
目的探讨无症状性冠状动脉内膜病变的发生频率及其与高血压、糖尿病和低密度脂蛋白胆固醇(LDL-C)的关系。方法应用冠状动脉血管内视镜技术对2003-06—2004-09日本医科大学附属千叶北总病院收治的120例陈旧性心肌梗死和稳定型心绞痛患者的非罪犯血管进行观察其有无黄色斑块、斑块破裂和(或)血栓形成等内膜病变,分别探讨它们与高血压、糖尿病和LDL-C的关系。结果120例患者(155支)非罪犯血管内,观察到内膜病变者80例(66·67%),其中合并高血压和高LDL-C血症者明显高于非内膜病变组(P<0·005),合并糖尿病者也高于非内膜病变组(P<0·05);观察到黄色斑块者30例(25·00%),其中合并高LDL-C血症者明显高于非内膜病变组(P<0·005);观察到斑块破裂和(或)伴有血栓形成等复杂斑块者50例(41·66%),其中合并高血压者明显高于非内膜病变组(P<0·005),合并高胆固醇血症者也高于非内膜病变组(P<0·01)。结论糖尿病、高血压及高LDL-C血症等是无症状性粥样斑块形成、不稳定甚至破裂的基础,所以,对糖尿病、高血压及血脂积极控制和治疗对ACS的预防是极其重要的。
Objective To investigate the incidence of asymptomatic coronary lesions and its relationship with hypertension, diabetes and low density lipoprotein cholesterol (LDL-C). Methods A total of 120 non-crippled vessels in patients with old myocardial infarction and stable angina pectoris who were admitted to Chiba General Hospital affiliated with Nihon University of Medical Science from June 2003 to June 2004 were observed with coronary artery endoscopy. Block, plaque rupture and / or thrombosis and other endometrial lesions, respectively, to explore their relationship with hypertension, diabetes and LDL-C. Results Of the 120 patients (155) who were not criminally involved, 80 (66.67%) cases of endometrial lesions were observed. Among them, those with hypertension and high LDL-C were significantly higher than those without endometriosis <0 · 005). Patients with diabetes mellitus also had a higher incidence of endometriosis than those without endometriosis (P <0.05). Thirty (25.00%) cases with yellow plaques were observed in those with high LDL-C (P <0 · 005). Fifty patients (41.66%) with plaque rupture and / or complicated with thrombosis were observed. The patients with complicated hypertension were significantly higher than those with non-endometriosis In non-endometrial lesions group (P <0 · 005), patients with hypercholesterolemia were also higher than non-endometrial lesions group (P <0.01). Conclusions Diabetes mellitus, hypertension and high LDL-C are the basis for the formation, instability and even rupture of asymptomatic atherosclerotic plaques. Therefore, it is very important to prevent and treat ACS with active control and treatment of diabetes mellitus, hypertension and blood lipids of.