广泛应用抗生素治愈感染的同时也导致了耐药 ,甚至是多药耐药菌株的增加 ,这就要求不断开发出新的抗生素。Ｔｏｍａｓｚ等最近研究表明 ,开发新抗生素最有希望的生化途径之一就是影响β 内酰胺类抗生素的作用靶点细菌细胞壁肽聚糖骨架 (胞壁质 )的代谢。其主要理由是 :肽聚糖只 The widespread use of antibiotics to cure infections also leads to an increase in drug-resistant and even multi-drug resistant strains, which requires the continuous development of new antibiotics. Recent studies by Tomasz et al. Have shown that one of the most promising biochemical pathways for the development of new antibiotics is the metabolism of the bacterial cell wall peptidoglycan (mural) that affects the target of the beta-lactam antibiotic. The main reason is: peptidoglycan only