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目的 :观察 β体甘草酸 (美能 )与α体甘草酸在慢性乙型肝炎治疗的对比研究。方法 :对 80例临床确诊为慢性乙型肝炎患者随机分两组 ,用双盲法作治疗 ,用药 16周后观察两组的肝功能、肝纤维化指标变化及副作用比较。结果 :实验组 (β体甘草酸 )在总胆红素、ALT ,AST ,HA(透明质酸 ) ,LN(层粘蛋白 ) ,ⅣC(Ⅳ型胶原 )的改善度较对照组 (α体甘草酸 )差异有极显著性意义 (P <0 .0 1) ,且副作用 β体甘草酸亦小于α体甘草酸。结论 :说明 β体甘草酸的临床效果优于α体甘草酸
Objective: To observe the comparison of β-glycyrrhizin (Amener) and α-glycyrrhizic acid in chronic hepatitis B treatment. Methods: Eighty patients with clinically diagnosed chronic hepatitis B were randomly divided into two groups. The patients were treated by double-blind method. After 16 weeks of treatment, liver function, changes of hepatic fibrosis and side effects were observed. Results: The improvement rate of total bilirubin, ALT, AST, HA (hyaluronic acid), LN (laminin) and Ⅳ C (type Ⅳ collagen) in the experimental group was significantly higher than that in the control group Acid) was significantly different (P <0. 01), and side effects of β-glycyrrhizic acid is also less than α-glycyrrhizic acid body. Conclusion: The clinical effect of β-glycyrrhizin is better than α-glycyrrhizic acid