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目的探讨凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]和血小板计数(PLT)对于肝硬化患者的临床意义。方法选取同期的55例肝硬化患者(肝硬化组)与50例正常体检者(对照组),比较分析肝硬化组于对照组及肝硬化是否出血患者的外周血PT、APTT、PLT水平。结果肝硬化组患者的PT(21.40±3.98)s、APTT(52.05±5.73)s长于对照组的(10.20±1.02)s、(32.46±2.58)s,PLT(57.29±16.57)×10~9/L低于对照组的(197.42±32.48)×10~9/L,差异具有统计学意义(t=19.322、22.208、-28.219,P<0.01)。肝硬化患者中出血患者PLT(48.29±19.57)×10~9/L较未出血患者的(68.42±10.26)×10~9/L少,且PT(23.40±4.63)s、APTT(60.05±3.04)s明显较未出血患者的(17.20±8.03)s、(46.01±9.44)s长,差异均具有统计学意义(t=-4.975、2.810、-8.848,P<0.01)。结论凝血功能及血小板对于衡量肝硬化患者出血倾向和预后判断有重要意义,值得推广。
Objective To investigate the clinical significance of coagulation function (prothrombin time (PT), activated partial thromboplastin time (APTT)] and platelet count (PLT) in cirrhotic patients. Methods 55 patients with cirrhosis (cirrhosis) and 50 normal controls (control group) were enrolled in this study. The levels of PT, APTT and PLT in cirrhotic patients with cirrhosis and cirrhosis were compared. Results Compared with the control group, the PT (21.40 ± 3.98) s and APTT (52.05 ± 5.73) s in patients with cirrhosis were significantly longer than those in the control group (10.20 ± 1.02) s, (32.46 ± 2.58) s and 57.29 ± 16.57 × 10 ~ 9 / L was lower than that of the control group (197.42 ± 32.48) × 10 ~ 9 / L, the difference was statistically significant (t = 19.322,22.208,28.219, P <0.01). The hemorrhage patients with cirrhosis PLT (48.29 ± 19.57) × 10 ~ 9 / L less than the non-bleeding patients (68.42 ± 10.26) × 10 ~ 9 / L less, and PT (23.40 ± 4.63) s, APTT ) s were significantly longer than those without hemorrhage (17.20 ± 8.03 s) (46.01 ± 9.44 s), the differences were statistically significant (t = -4.975,2.810, -8.848, P <0.01). Conclusion Coagulation and platelets are important for measuring the bleeding tendency and prognosis of patients with cirrhosis. It is worth promoting.