Background:Few studies have addressed whether abnormalities in the lenticular nucleus (LN) are characteristic transcranial sonography (TCS) echo features in patients with primary dystonia.This study aimed to explore alterations in the basal ganglia in different forms of primary focal dystonia.Methods:A cross-sectional observational study was performed between December 2013 and December 20 1 4 in 80 patients with different forms of primary focal dystonia and 55 neurologically normal control subjects.TCS was performed in patients and control subjects.Multiple comparisons of multiple rates were used to compare LN hyperechogenicity ratios between control and patient groups.Results:Thirteen individuals were excluded due to poor temporal bone windows,and two subjects were excluded due to disagreement in evaluation by sonologists.Totally,70 patients (cervical dystonia,n =30;blepharospasm,n =30;oromandibular dystonia,n =10) and 50 normal controls were included in the final analysis.LN hyperechogenicity was observed in 51％ (36/70) of patients with primary focal dystonia,compared with 12％ (6/50) of controls (P ＜ 0.001).Substantia nigra hyperechogenicity did not differ between the two groups.LN hyperechogenicity was observed in 73％ (22/30) of patients with cervical dystonia,a greater prevalence than in patients withblepharospasm (33％,10/30,P =0.002) and oromandibular dystonia (40％,4/10,P =0.126).LN hyperechogenicity was more frequently observed in patients with cervical dystonia compared with controls (73％ vs.12％,P ＜ 0.001);however,no significant difference was detected in patients with blepharospasm (33％ vs.12％,P =0.021) or oromandibular dystonia (40％ vs.12％,P =0.088).Conclusions:LN hyperechogenicity is more frequently observed in patients with primary focal dystonia than in controls.It does not appear to be a characteristic TCS echo feature in patients with blepharospasm or oromandibular dystonia.