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用免疫组化 LSAB 法检测组织蛋白酶 D(CD)在86例乳腺浸润性导管癌的间质细胞和癌细胞中的表达情况。结果:间质细胞和癌细胞的阳性率分别为66.2%(57/86)和54.6%(47/86)。CD 在间质细胞中的表达强度高于癌细胞,差别有显著性意义。统计学分析表明,间质细胞的 CD 高表达与乳癌的区域淋巴结转移、远处转移和小于5年生存期呈正相关,而癌细胞的 CD 表达与上述预后指标无关。说明间质细胞的 CD 表达可作乳癌预后的一种指标。本文还就 CD 在间质细胞的阳性率和表达强度高于癌细胞的意义作了讨论。本研究提示,间质细胞可能在乳癌的局部浸润和转移中起重要作用。
The expression of cathepsin D (CD) in 86 mesangial infiltrating ductal carcinoma mesangial cells and cancer cells was detected by immunohistochemical LSAB assay. Results: The positive rates of stromal cells and cancer cells were 66.2% (57/86) and 54.6% (47/86), respectively. The intensity of CD expression in stromal cells was higher than that of cancer cells, and the difference was significant. Statistical analysis showed that the high CD expression of mesenchymal cells was positively correlated with regional lymph node metastasis, distant metastasis, and less than 5-year survival of breast cancer. The CD expression of cancer cells was not related to the above prognostic indicators. It shows that the CD expression of stromal cells can be used as an indicator of the prognosis of breast cancer. This article also discusses the significance of the positive rate and expression intensity of CD in stromal cells higher than that of cancer cells. This study suggests that stromal cells may play an important role in the local invasion and metastasis of breast cancer.