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目的 探讨重症创伤患者血清降钙素原(PCT)水平变化特点,分析其与多脏器功能衰竭(MODS)的关系.方法 分别检测运城市中心医院2013年10月至2018年10月收治的重症创伤合并MODS患者(MODS组,40例)和未发生MODS患者(非MODS组,62例)入院1d、3d、7d血清PCT水平,分析PCT与创伤严重程度评分(ISS)、序贯器官衰竭(SOFA)评分、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)评分、预后的关系,应用受试者工作特征(ROC)曲线分析PCT对重症创伤患者发生MODS以及重症创伤合并MODS患者预后的预测价值.结果 MODS组入院1d、3d、7d血清PCT水平分别为(8.25±2.35) μg/L、(7.26±2.49) μg/L、(3.62±1.75) μg/L,均高于对照组,差异均有统计学意义(=7.561、9.561、8.251,均P＜0.05).MODS组患者血清PCT水平均随APACHEⅡ评分、ISS评分的增高而升高,差异均有统计学意义(F=12.108、9.173,均P＜0.05),死亡组患者血清PCT水平高于存活组[(11.82±3.75) μg/L比(4.92±1.26) μg/L],差异有统计学意义(t=7.959,P＜0.05).PCT预测重症创伤患者MODS曲线下面积达0.848,灵敏度、特异度分别为80.00％(32/40)、82.50％(33/40),预测重症创伤合并MODS患者预后曲线下面积达0.747,灵敏度、特异度分别为77.50％(31/40)、72.50％(29/40).结论 重症创伤合并MODS患者血清PCT水平明显高于未发生MODS患者,且其水平与创伤、病情进展程度,预测MODS发生及其预后有重要价值.“,”Objective To investigate the changes of serum procalcitonin (PCT) level in patients with severe trauma,and to analyze its relationship with multiple organ failure (MODS).Methods From October 2013 to October 2018,the serum PCT levels were measured in 40 patients with severe trauma complicated with MODS (MODS group:40 cases) and 62 patients without MODS (non-MODS group:62 cases) in Yuncheng Central Hospital.The relationship between PCT and severity of trauma score (ISS),sequential organ failure (SOFA),acute physiology and chronic health status score (APACHE Ⅱ) and prognosis was analyzed.The predictive value of PCT in the prognosis of patients with MODS and severe trauma combined with MODS was analyzed by ROC.Results The serum PCT levels of the MODS group were (8.25 ± 2.35) μg/L,(7.26 ± 2.49) μg/L,(3.62 ± 1.75) μg/L on the 1 st,3rd and 7th day after admission,respectively,which were higher than those of the control group (t =7.561,9.561,8.251,all P ＜0.05).The serum PCT level in the MODS group increased with the increase of APACHE Ⅱ score and ISS score(F =12.108,9.173,all P ＜ 0.05).The serum PCT level in the death group was higher than that in the survival group[(11.82 ± 3.75) μg/L vs.(4.92 ± 1.26) μg/L],and the difference was statistically significant (t =7.959,P ＜0.05).The area under MODS curve predicted by PCT for severe trauma patients was 0.848,with sensitivity and specificity of 80.00％ (32/40),82.50％ (33/40),respectively.The area under MODS curve predicted by PCT was 0.747,with sensitivity and specificity of 77.50％ (31/40),72.50％ (29/40),respectively.Conclusion The serum PCT level in patients with severe trauma complicated with MODS is significantly higher than that in patients without MODS,and its level is closely related to trauma,disease progression and prognosis.It is of great value to predict the occurrence and prognosis of MODS.