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JAK-STAT是细胞因子发挥生物学功能的重要信号转导途径。在正常细胞中激活STATs是一个瞬时的过程,而在癌细胞中,STATs蛋白被持续激活,在肺癌时表达不一。有关STAT信号途径的研究为人类肿瘤的干预治疗提供了新的分子标靶。
JAK-STAT is an important signal transduction pathway for cytokines to exert biological functions. Activation of STATs in normal cells is an instantaneous process, whereas in cancer cells STATs are activated continuously and are expressed differently in lung cancers. Studies on the signaling pathways of STAT have provided new molecular targets for the interventional treatment of human tumors.