骨质疏松症是以骨量减少、骨的微观结构退化为特征的,致使骨的脆性增加以及易于发生骨折的一种全身性骨骼疾病,其发生受多种因素的影响。近年来,随着研究的深入,人们发现成骨细胞增殖及骨形成过程,受到一系列细胞因子、信号分子的影响和控制,其中除与MAPKs及Smads途径外,Wnt信号通路逐渐成为骨形成调节作用机制研究的新热点。 Osteoporosis is characterized by a decrease in bone mass, the degradation of the microscopic structure of the bone, a systemic skeletal disease that results in an increase in the fragility of the bone and is prone to fracture, and its occurrence is influenced by a number of factors. In recent years, with the deepening of research, people found that osteoblast proliferation and bone formation process, by a series of cytokines, signaling molecules and control, in addition to the MAPKs and Smads pathway, Wnt signaling pathway gradually become bone formation regulation New research hotspot of mechanism of action.