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目的:探讨消癌平注射液对乳腺癌患者术后免疫功能的影响。方法:选取2013年6月至2015年7月84例术后乳腺癌患者,随机分为对照组(n=42)及观察组(n=42)。两组在术后同时行CMF[环磷酰胺(CTX)+甲氨蝶呤(MTX)+氟尿嘧啶(5-FU)]化疗方案。对照组仅行化疗治疗,观察组在对照基础上静脉滴注消癌平注射液。对比分析两组患者的治疗效果、术后免疫功能、炎症因子及血管内皮生长因子(VEGF)水平的变化。结果:观察组患者治疗后Th17细胞比率低于对照组,而Th17/Treg、CD4~+CD25~+Treg细胞的比率则高于对照组(P<0.05)。观察组患者术后白细胞介素(IL)-1,6、肿瘤细胞坏死因子-α(TNF-α)及VEGF水平显著低于对照组(P<0.05)。结论:消癌平注射液能有效改善乳腺癌化疗患者的免疫功能,降低化疗对患者的毒副作用,提高治疗效果。
Objective: To investigate the effect of Xiaojianping injection on postoperative immune function in patients with breast cancer. Methods: Eighty-four patients with postoperative breast cancer from June 2013 to July 2015 were randomly divided into control group (n = 42) and observation group (n = 42). Both groups underwent concurrent CMF chemotherapy with CTX + methotrexate (MTX) + fluorouracil (5-FU). The control group was treated with chemotherapy only. The observation group was given intravenous drip of Xiaojinping injection on the basis of the control. The effects of treatment, postoperative immune function, inflammatory factors and the level of vascular endothelial growth factor (VEGF) were compared between the two groups. Results: The ratio of Th17 cells in the observation group was lower than that in the control group, while the ratio of Th17 / Treg and CD4 + CD25 + Treg cells was higher than that of the control group (P <0.05). The levels of IL-1, TNF-α and VEGF in the observation group were significantly lower than those in the control group (P <0.05). Conclusion: Xiaofangping injection can effectively improve the immune function of patients with breast cancer chemotherapy, reduce the side effects of chemotherapy on patients and improve the therapeutic effect.