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目的探讨帕罗西汀联合行为干预治疗脑卒中后抑郁患者的有效性。方法将2006年7月至2011年1月我院神经内、外科确诊为脑卒中的72例患者按随机数字表法分为对照组和干预组(n=36),对照组予以口服帕罗西汀和常规治疗护理,干预组在对照组基础上同时进行针对性的行为干预,比较两组患者的康复效果及生活质量。两组治疗前后分别进行HAMD评分、Barthel指数(BI)评分法和生活质量综合评定问卷-74(GQOLI-74)的评定。结果治疗后,干预组总有效率(94.4%)显著高于对照组(75.0%)(χ2=5.528,P<0.05)。两组间在治疗前HAMD评分、BI评分和GQOLI-74评分差异均无统计学意义(P>0.05);治疗后,两组HAMD评分均下降,BI评分均上升,组内各项评分较治疗前均明显改善(P<0.05),两组GQOLI-74评分除物质生活因子外,差异均有统计学意义(P<0.05)。结论脑卒中后抑郁患者予以帕罗西汀联合行为干预治疗,能促进患者的康复,提高患者的生活质量。
Objective To explore the effectiveness of paroxetine combined with behavioral intervention in the treatment of post-stroke depression. Methods Seventy-two patients with neurological and surgical diagnosis of stroke in our hospital from July 2006 to January 2011 were divided into control group and intervention group (n = 36) according to random number table. The control group was treated with oral paroxetine and Routine treatment and nursing intervention group on the basis of the control group at the same time targeted interventions, rehabilitation outcomes and quality of life of the two groups were compared. Before and after treatment, HAMD score, Barthel index (BI) score and QOL-74 (QOLI-74) were assessed before and after treatment. Results After treatment, the total effective rate (94.4%) in the intervention group was significantly higher than that in the control group (75.0%) (χ2 = 5.528, P <0.05). There was no significant difference in HAMD score, BI score and GQOLI-74 score between the two groups before treatment (P> 0.05). After treatment, the HAMD scores of both groups decreased and the BI scores increased. (P <0.05). The GQOLI-74 scores of two groups were all significantly different from those of the control group (P <0.05). Conclusions Paroxetine combined with behavioral intervention can reduce the post-stroke depression, promote the recovery of patients and improve the quality of life of patients.