论文部分内容阅读
目的研究癫痫患者智力状况与脑脊液γ-氨基丁酸(CSF-GABA)含量的关系。方法采用韦氏智力量表对52例癫痫患者进行智商测定,应用反相高效液相色谱柱前衍生法测定其CSF-GABA含量,并对影响癫痫患者智力的因素进行分析。结果52例癫痫患者中总智商(FIQ)≤89者20例,占38%。癫痫患者智力状况主要与CSF-GABA含量、文化程度、发作类型呈正相关,与患者年龄呈负相关。其中以CSF-GABA含量对言语智商(VIQ)、操作智商(PIQ)、FIQ影响作用明显(P<0.01或P<0.05)。结论癫痫患者智力障碍与CSF-GABA含量有关。
Objective To study the relationship between the mental status of patients with epilepsy and the content of γ-aminobutyric acid (CSF-GABA) in cerebrospinal fluid. Methods Fifty-two patients with epilepsy were measured by using the Wechsler Intelligence Scale. The CSF-GABA levels were determined by RP-HPLC, and the factors influencing the intelligence of patients with epilepsy were analyzed. Results 52 patients with epilepsy in total intelligence (FIQ) ≤ 89 in 20 cases, accounting for 38%. The intelligence status of patients with epilepsy was positively correlated with CSF-GABA content, education level and type of seizure, and was negatively correlated with patient’s age. The effects of CSF-GABA on VIQ, PIQ and FIQ were significant (P <0.01 or P <0.05). Conclusion The mental retardation in patients with epilepsy is related to the content of CSF-GABA.