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摘要目的确定成像测量法在轻度或中度肺气肿和呼吸道疾病中决定慢性阻塞性肺病(COPD)的症状和运动受限程度的作用。材料与方法受试者(n=116)为全球招募的COPD病人(GOLD)U级(未分类)或Ⅰ~Ⅳ级,签署经伦理委员会批准的知情同意书并符合HIPAA协议。所有受试者接受肺容量测定和体积描记,完成St George呼吸问卷(SGRQ),完成6 min步行试验,记录6 min步行距离(6MWD),进行超极化~3He-MRI和CT检查。采用MRI表观扩散系数(ADC)和CT衰减直方图[衰减值取-950 HU或更小值(RA_(950))]上的相
Abstract Objective To determine the role of imaging measurement in determining the symptoms and locomotor limitations of chronic obstructive pulmonary disease (COPD) in mild or moderate emphysema and respiratory disease. MATERIALS AND METHODS Subjects (n = 116) were GOLD class U (unclassified) or grade I to IV enrolled globally and signed an informed consent form approved by the Ethics Committee and in compliance with the HIPAA agreement. All subjects underwent lung volumetric measurements and plethysmography. The St George Respiratory Questionnaire (SGRQ) was completed and a 6-min walk test was performed. The 6-minute walk distance (6MWD) was recorded and hyperpolarized ~ 3He-MRI and CT were performed. Using MRI apparent diffusion coefficient (ADC) and CT attenuation histograms (attenuation values taken as -950 HU or less (RA_ (950))]