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食管腔粘液24小时pH值监测被视为“金标准”已广泛运用于临床，对胃食管返流性疾病进行检查与诊断。分别对食管癌（中下段）组和贲门癌组病人（每组各15人）进行了治疗前食管腔粘液24小时pH值监测，对两组所测数值进行比较。结果表明，贲门癌组存在轻度胃食管返流，类似生理性返流。食管癌组则呈明显的病理性返流，其差别具有统计学意义（pH＜4总时间：贲门癌组为1．2％±0．3％；食管癌组为6.6％±3.8％；P＜0．01）。考虑其原因与进食困难造成的进食时间延长，使胃酸分泌量相对增加；食管完整性受到破坏，影响了食管的正常蠕动及清酸功能；唾液分泌相对减少及吞咽障碍，影响了唾液中和酸性返流作用有关。
The 24-hour pH monitoring of esophageal mucus is considered as the “gold standard” and has been widely used in clinical practice for the examination and diagnosis of gastroesophageal reflux disease. The 24-hour pH monitoring of esophageal cavity mucous before treatment was performed on patients with esophageal cancer (middle and lower segment) and cardiac cancer patients (15 individuals in each group), and the values measured in the two groups were compared. The results showed that there was mild gastroesophageal reflux in the cardia cancer group, similar to physiological regurgitation. Esophageal cancer group showed significant pathological reflux, the difference was statistically significant (pH <4 total time: 1.2% ± 0.3% in the cardia cancer group; 6.6% ± 3.8% in the esophageal cancer group; P <0.01). Taking into account the causes and eating difficulties caused by the prolonged eating time, so that the relative increase in gastric acid secretion; esophageal integrity is damaged, affecting the normal motility of the esophagus and acid function; relative reduction in salivation and swallowing disorders, affecting the saliva and acidity The effect of reflux is related.