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总结国内外关于线粒体融合蛋白Mfn1和Mfn2的结构、功能及其在肿瘤发生发展中发挥作用的研究进展。方法:应用Medline及CNKI期刊全文数据库系统,以“线粒体融合蛋白(Mfn1和Mfn2)、增殖抑制基因(HSG)、肿瘤、肿瘤细胞系”为关键词,检索1998-01-2009-12的相关文献。纳入标准:1)Mfn1和Mfn2的结构及其功能;2)HSG的发现及其名称来源;3)Mfn1和Mfn2与HSG的关系;4)HSG与肿瘤组织及肿瘤细胞的关系。根据纳入标准,精选符合分析的22篇文献。结果:Mfn1和Mfn2在线粒体融合中发挥着重要的作用,Mfn1和Mfn2的突变与许多疾病的发生与发展有关,如神经病,肥胖症以及血管疾病等。特别是Mfn2作为一种新的肿瘤相关基因,被发现在多种肿瘤及其细胞系中具有抑制增殖的作用。结论:根据线粒体融合蛋白具有抑制细胞增殖这一特点,靶向于其中的信号通路对其进行加强为肿瘤的基因治疗提供了一个新的思路。
The research progress on the structure and function of mitochondrial fusion proteins Mfn1 and Mfn2 at home and abroad and their roles in tumorigenesis were summarized. Methods: Using the keywords “Medline” and “CNKI” periodical full-text database system, with the key words of “mitochondrial fusion protein (Mfn1 and Mfn2), proliferation inhibitory gene (HSG), tumor and tumor cell line” Related documents Inclusion criteria: 1) the structure and function of Mfn1 and Mfn2; 2) the discovery of HSG and its source; 3) the relationship between Mfn1 and Mfn2 and HSG; 4) the relationship between HSG and tumor tissue and tumor cells. Based on the inclusion criteria, 22 articles were selected that matched the analysis. Results: Mfn1 and Mfn2 play an important role in mitochondrial fusion. The mutations of Mfn1 and Mfn2 are related to the occurrence and development of many diseases such as neuropathy, obesity and vascular diseases. In particular, Mfn2, a novel tumor-associated gene, has been found to have an inhibitory effect on proliferation in a variety of tumors and their cell lines. Conclusion: According to the characteristic of mitochondrial fusion protein inhibiting cell proliferation, the targeting of the signaling pathway to strengthen it provides a new idea for the gene therapy of tumors.