论文部分内容阅读
目的比较西罗莫司药物洗脱支架和金属裸支架治疗冠心病患者的远期安全性。方法选择北京安贞医院2000年1月至2004年8月置入金属裸支架的冠心病患者505例,与2004年1月至2005年1月置入西罗莫司洗脱支架的984例冠心病患者进行历史性对照分析,比较两组患者支架术后随访2年的死亡、支架内血栓、非致死性心肌梗死发生率。结果两组患者在合并吸烟、高血压、高血脂、糖尿病所占比例及冠状动脉病变支数方面差异均无统计学意义。西罗莫司洗脱支架组患者平均年龄较大、分叉病变比例高、置入支架平均直径小且平均支架长度较长。临床随访2年,两组患者生存率、支架内血栓、非致死性心肌梗死及死亡/非致死性心肌梗死发生率方面差异均无统计学意义(分别为99.3%、1.3%、1.1%、1.8%和98.3%、1.7%、1.7%、3.5%,P>0.05)。结论西罗莫司洗脱支架和金属裸支架在冠心病患者中应用的远期安全性相似。
Objective To compare the long-term safety of sirolimus-eluting stents and bare-metal stents in patients with coronary heart disease. Methods A total of 505 coronary heart disease patients with bare metal stents were enrolled in the hospital from January 2000 to August 2004 in Beijing Anzhen Hospital. From January 2004 to January 2005, 984 coronary crowns with sirolimus-eluting stents A historical control study of patients with heart disease was conducted. The 2-year follow-up, stent thrombosis, and non-fatal MI were compared between the two groups. Results There was no significant difference between the two groups in terms of smoking, hypertension, hyperlipidemia, the proportion of diabetes and the number of coronary lesions. Patients in the sirolimus-eluting stent group were older, had a higher percentage of bifurcation lesions, had smaller average stent placement diameter, and longer average stent length. There was no significant difference in survival rate, stent thrombosis, non-fatal myocardial infarction and death / non-fatal myocardial infarction between the two groups after clinical follow-up of 2 years (99.3%, 1.3%, 1.1%, 1.8 % And 98.3%, 1.7%, 1.7%, 3.5%, P> 0.05). Conclusion Long-term safety of sirolimus-eluting stents and bare-metal stents in patients with coronary heart disease is similar.