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目的探讨高葡萄糖钳夹技术(HGCT)在糖尿病患者胰岛B细胞功能评估中的应用。方法研究对象分为糖尿病非胰岛素注射组(NIns组,n=8)和糖尿病胰岛素注射组(Ins组,n=10)及正常对照组(NC组,n=10)。用改良评估法与传统计算方法计算HGCT过程中胰岛素增加值,评价对糖尿病患者胰岛B细胞功能。结果NIns组按胰岛素增加值计算有8例判为第一时相胰岛素分泌(1PH)减退,6例判为第二时相胰岛素分泌(2PH)及最大胰岛素分泌量(MIS)减退,与传统计算方法比较差异无统计学意义(P>0.05)。Ins组按传统法计算的1PH、2PH及MIS均高于NIns组,与临床实际情况不符,而按胰岛素增加值计算Ins组的△2PH及△MIS均低于NIns组。结论对于需外源性胰岛素治疗的2型糖尿病患者,改良计算法优于传统计算法。
Objective To investigate the application of high glucose clamp technique (HGCT) in the assessment of pancreatic islet B cell function in diabetic patients. Methods The subjects were divided into non-insulin diabetic group (NIns group, n = 8) and diabetic insulin group (n = 10) and normal control group (NC group, n = 10). The improved assessment method and the traditional calculation method were used to calculate the added value of insulin during HGCT and evaluate the function of islet B cells in diabetic patients. Results In the NIns group, 8 cases were judged as the first phase insulin secretion (1PH) decrease and the second phase insulin secretion (2PH) and the maximal insulin secretion (MIS) decrease in 6 cases, which were compared with the traditional calculation There was no significant difference in the methods (P> 0.05). 1PH, 2PH and MIS in Ins group were higher than those in NIns group according to the traditional method, which was not in accordance with the actual clinical situation. However, △ 2PH and △ MIS in Ins group were lower than those in NIns group by Insulin added value. Conclusion For patients with type 2 diabetes requiring exogenous insulin therapy, the improved method is superior to the traditional method.