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本研究对经冠状动脉（冠脉）造影确定冠脉狭窄≥５０％的冠心病（ＣＨＤ）患者１８例，对照组１１例，采用平板运动试验诱发心绞痛（ＡＰ），同步检测运动前后血浆组织型纤溶酶原激活剂（ｔＰＡ）及其抑制物（ＰＡＩ）、纤维蛋白原（Ｆｇ）、血栓素Ｂ２（ＴＸＢ２）、６－酮类固醇－前列腺素Ｆ１０（６－ｋｅｔｏＰＧＦ１０）、肾素活性（ＰＲＡ）及血管紧张素Ⅱ（ＡｎｇⅡ）的变化，并根据平板运动试验结果将ＣＨＤ患者分为ＡＰ、非ＡＰ及阴性三组（各６例）进行比较。结果表明：ＡＰ组运动前后血浆Ｆｇ、ＰＡＩ活性、ＴＸＢ２、ＡｎｇⅡ水平均显著高于非ＡＰ组、阴性组及对照组，并且运动后的血浆ＴＸＢ２、ＡｎｇⅡ水平增加更显著；而运动前后的血浆ｔ－ＰＡ含量及活性水平却结果相反。揭示，基础水平血浆ｔ－ＰＡ活性低、ＰＡＩ活性高的ＣＨＤ患者，其血浆ＴＸＢ２、ＡｎｇⅡ水平亦高，ｔ－ＰＡ的促血小板解聚作用减弱，剧烈运动易进一步强烈激活血小板及肾素－血管紧张素系统诱发ＡＰ发作。
In this study, 18 patients with coronary heart disease (CHD) whose coronary stenosis≥50% were diagnosed by coronary angiography (CAG), and 11 patients as control group. Angina pectoris (AP) was induced by treadmill exercise test. (TPA) and its inhibitors (PAI), fibrinogen (Fg), thromboxane B2 (TXB2), 6-ketoPGF10 and renin activity ) And angiotensin Ⅱ (Ang Ⅱ). According to treadmill exercise test results, CHD patients were divided into AP, non-AP and negative groups (6 in each) for comparison. The results showed that the levels of Fg, PAI, TXB2 and AngⅡ in plasma before and after exercise in AP group were significantly higher than those in non-AP group, negative group and control group, and the plasma TXB2 and AngⅡ levels increased more significantly after exercise. -PA content and activity level but the opposite result. Revealed that basal levels of plasma t-PA activity is low, PAI activity in patients with CHD, plasma TXB2, Ang Ⅱ level is also high, t-PA platelet depolymerization reduced, strenuous exercise tends to further strongly activate platelets and renin - blood vessels Tension system induced AP episodes.