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目的观察盐酸米诺环素软膏在成人中、重度牙周病患者牙周-正畸联合治疗中的应用。方法 40例成人中、重度牙周病患者,采用牙周-正畸联合治疗,按数字随机表法分为2组(各20例),牙周治疗实验组应用盐酸米诺环素软膏,对照组常规双氧水冲洗加碘甘油安抚;牙周治疗3个月后开始正畸治疗。治疗前、后均探诊牙周袋深度(PD)、检测牙龈指数(GI)及临床附着水平(CAL)。摄X线曲面断层片测量前牙间牙槽骨高度,并进行比较。随访1年。结果治疗后较治疗前2组PD、GI均明显降低(P均<0.05);CAL及前牙间牙槽骨高度略有降低,但差异无统计学意义(P均>0.05)。随访显示,2组牙齿松动度稳定在Ⅰ度以下,移位牙得以复位,牙周袋变浅或消失,牙龈无明显炎症、出血,后牙尖窝关系良好,咀嚼功能改善。结论盐酸米诺环素软膏局部治疗与常规双氧水冲洗加碘甘油安抚牙周局部治疗联合正畸治疗,均可改善牙周状况和错畸形,且效果稳定。
Objective To observe the application of minocycline hydrochloride ointment in periodontal-orthodontic treatment in adults with severe periodontal disease. Methods 40 cases of adult patients with severe periodontal disease were treated with periodontal-orthodontic treatment. The patients were divided into 2 groups (20 cases each) according to the digital random table method. In the periodontal treatment group, minocycline hydrochloride ointment was used, Group conventional hydrogen peroxide iodine glycerol to soothe; periodontal treatment began 3 months after orthodontic treatment. Periodontal pocket depth (PD), gingival index (GI) and clinical attachment level (CAL) were measured before and after treatment. The X-ray surface tomography was used to measure the height of alveolar bone between anterior teeth and compare them. Followed up for 1 year. Results After treatment, the PD and GI of two groups were significantly lower than those before treatment (all P <0.05). The height of alveolar bone between CAL and anterior teeth decreased slightly, but the difference was not statistically significant (all P> 0.05). Follow-up showed that the degree of loosening of the two groups of teeth was stable below Ⅰ degree, the displaced teeth could be reset, the periodontal pocket became shallow or disappeared, the gums had no obvious inflammation and hemorrhage, the posterior teeth had a good relationship and the chewing function improved. Conclusion Local treatment of minocycline hydrochloride ointment combined with routine hydrogen peroxide irrigation plus iodized glycerol pacification periodontal treatment combined with orthodontic treatment can improve periodontal status and malocclusion, and the effect is stable.