据报道,胃酶抑素、胰凝乳蛋白酶抑素及亮肽素等蛋白酶抑制剂可抑制诺氏疟原虫裂殖子进入红细胞。作者曾证明,脑型疟疾患者发病初期的血清具有较高的疟原虫生长抑制活性。本文进一步研究了疟疾患者血清蛋白酶抑制剂的含量与抑制体外恶性疟原虫生长作用的关系。对7名脑型疟和2名急性疟疾患者的研 It has been reported that protease inhibitors such as pepstatin, chymotrypsin and leupeptin inhibit the entry of Plasmodium knowlesi into the erythrocytes. The authors have demonstrated that serums from the onset of cerebral malaria patients have a high Plasmodium growth inhibitory activity. This article further studies the relationship between the levels of serum protease inhibitors in malaria patients and the inhibition of growth of Plasmodium falciparum in vitro. Study of 7 cerebral malaria patients and 2 acute malaria patients