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目的探讨伴脑型脂肪酸结合蛋白(brain fatty acid binding protein,B-FABP)增高的缺血性卒中(ischemic stroke,IS)患者相关危险因素。方法共纳入85例IS患者,且均证实B-FABP水平﹥11μg/L,同时随机抽取90例B-FABP未增高的IS患者作为对照组。采用免疫透射比浊法检测患者血清B-FABP水平。应用非条件Logistic回归分析进行多因素分析。结果单因素t或χ2检验分析结果表明:男性、高血压病史、糖尿病史、冠心病史、吸烟史、饮酒史、TG、TC、LDL-C及HDL-C与伴B-FABP增高的缺血性卒中的发生存在相关性(P﹤0.05);其中男性、高血压病史、糖尿病史、冠心病史、吸烟史、饮酒史、TG、TC、LDL-C与IS患者B-FABP增高呈正相关(P﹤0.05);而与HDL-C呈负相关关系(P﹤0.05)。进一步行多因素分析结果表明:高血压病史、糖尿病病史是IS患者B-FABP增高的独立危险因素;HDL-C是IS患者B-FABP增高的保护因素。结论高血压、糖尿病及HDL-C可以影响IS患者BFABP水平,因此在临床工作中,需要对上述可干预的危险因素进行干预,以期降低IS的发生率。
Objective To investigate the risk factors of ischemic stroke (IS) patients with elevated brain fatty acid binding protein (B-FABP). METHODS: A total of 85 patients with IS were enrolled. All of them confirmed that the B-FABP level was> 11μg / L. At the same time, 90 IS patients without B-FABP were randomly selected as the control group. Serum B-FABP levels were measured by immunoturbidimetry. Unconditional logistic regression analysis was used for multivariate analysis. Results The results of one-way t-test or χ2 test showed that there was a significant difference between the two groups in male, history of hypertension, history of diabetes, history of coronary heart disease, smoking history, drinking history, TG, TC, LDL-C and HDL- (P <0.05). Among them, male, history of hypertension, history of diabetes, history of coronary heart disease, smoking history, drinking history, TG, TC and LDL-C were positively correlated with the increase of B-FABP P <0.05), but negatively correlated with HDL-C (P <0.05). Further multivariate analysis showed that the history of hypertension and diabetes mellitus were independent risk factors of increased B-FABP in IS patients. HDL-C was the protective factor of elevated B-FABP in IS patients. Conclusions Hypertension, diabetes mellitus and HDL-C can affect the level of BFABP in IS patients. Therefore, we need to intervene in the above interventional risk factors in order to reduce the incidence of IS.