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本项研究是探讨肠化生和组织类型不同的胃癌在发生上的关系。作者认为,采用Burstone和Folk的组织化学方法,在切除的胃标本上,从大体上显示LAP(leucine aminopeptidase亮氨酸氨基肽酶)的存在,有利于补充组织学的分析。正常时,LAP仅存在于小肠细胞内,但也出现在发生了肠化生的胃粘膜。Graham及shade,Stemmermann及Hayashi等曾用ALP(alkaline phosphatase硷性磷酸酶)及其改进法进行过类似的研究。Sugimura等人曾使用二糖酶法检测胃粘膜肠化生。Kawachi等应用此法发现各种二糖酶的分布的不同。Stemmermann和Hayashi注意到一些在显微镜下所判定的肠化生区域,并不被以上作者们用的方法染色。
This study was to investigate the relationship between intestinal metaplasia and the different types of gastric cancer. The authors believe that the use of the histochemical methods of Burstone and Folk, in the resection of gastric specimens, generally shows that the presence of LAP (leucine aminopeptidase leucine aminopeptidase) is conducive to complement histological analysis. Normally, LAP exists only in small intestinal cells, but it also occurs in the gastric mucosa where intestinal metaplasia occurs. Graham and Shade, Stemmermann, and Hayashi have conducted similar studies using ALP (alkaline phosphatase) and its modified methods. Sugimura et al. used the disaccharide enzymatic method to detect intestinal metaplasia of gastric mucosa. Kawachi et al. used this method to find out the differences in the distribution of various disaccharidases. Stemmermann and Hayashi noticed that some of the areas of intestinal metaplasia identified under the microscope were not stained by the methods used by the authors.