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BMY40062是对革蓝氏阳性菌和阴性菌有抗菌活性的广谱抗菌剂。本文研究了BMY40062的体外和体内抗菌活性,与环丙氟哌酸和氟嗪酸进行比较。体外试验结果表明,对葡萄球菌,链球菌和肠球菌的抗菌活性,BMY40062比环丙氟哌酸强3倍,比氟嗪酸强4～8倍;对肠杆菌科、绿脓杆菌和不动杆菌属的大多数菌株的活性,BMY40062比环丙氟哌酸弱2倍,比氟嗪酸强2倍;对脆弱拟杆菌和艰难梭菌的活性,本品与氟嗪酸相似,而强于环丙氟哌酸;本品对尿素溶酶体和砂眼衣原体的活性与四环素相似,分别为环丙氟哌酸和氟嗪酸活性的4倍和16倍。BMY40062的体外抗菌活性受pH及镁离子的影响,但这些因素对BMY40062对绿脓杆菌活性的影响较对环丙氟哌酸和氟嗪酸的影
BMY40062 is a broad-spectrum antibacterial agent that has antibacterial activity against gram-positive and -negative bacteria. In this paper, the antibacterial activity of BMY40062 in vitro and in vivo was compared with that of ciprofloxacin and ofloxacin. In vitro test results showed that the antibacterial activity against Staphylococcus aureus, Streptococcus and Enterococcus, BMY40062 3 times stronger than Ciprofloxacin, 4 to 8 times stronger than trifluoperazine; For Enterobacteriaceae, Pseudomonas aeruginosa and immobility Most strains of Bacillus activity, BMY40062 2 times weaker than ciprofloxacin, 2 times stronger than triflum acid; Bacteroides fragilis and Clostridium difficile activity, this product is similar to olanzapine, but stronger than Ciprofloxacin; This product of ureas and Chlamydia trachomatis and tetracycline activity similar, respectively, ciprofloxacin and trifloic acid activity 4 times and 16 times. The in vitro antibacterial activity of BMY40062 was affected by pH and magnesium ions, but the influence of these factors on the activity of BMY40062 against Pseudomonas aeruginosa was better than that of ciprofloxacin and