近年随着研究的深入,炎症反应所致的组织损伤在多脏器衰竭(MOF)发病机理中的作用引起了普遍的重视。因此,介导炎症反应的重要毒性介质如肿瘤坏死因子(TNF)、内毒素、白细胞介素-1(IL-1])、血小板活化因子(PAF)、花生酸系统及氧自由基等,也受到了密切的关注。TNF以其广泛多样的生物学活性,与其他炎症 In recent years, with the deepening of research, the role of inflammation-induced tissue damage in the pathogenesis of multiple organ failure (MOF) has attracted widespread attention. Therefore, important toxic mediators such as tumor necrosis factor (TNF), endotoxin, interleukin-1 (IL-1), platelet activating factor (PAF), arachidonic acid system and oxygen free radical which mediate inflammatory reaction also Has been closely watched. TNF has a wide variety of biological activities with other inflammations