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目的:探讨30岁以下乳腺癌的临床特点、无瘤生存率和影响预后的因素。方法:回顾性分析我院1989年12月~2000年12月收治的102例30岁以下乳腺癌患者的临床资料,观察患者放射治疗后长期无瘤生存率,分析放射治疗临床特点及影响预后的因素。结果:肿瘤直径≤3 cm和>3 cm的患者其3年无瘤生存率分别为91.67%、87.04%(P<0.01)。腋窝淋巴结转移阴性者3年、5年无瘤生存率分别为92.11%、81.58%,1~3枚阳性者3年、5年无瘤生存率分别为88.24%、70.59%,≥4枚阳性者3年、5年无瘤生存率分别为84.00%、40.00%。放射治疗组3年、5年无瘤生存率分别为94.44%和90.28%,未行放射治疗组3年、5年无瘤生存率分别为76.67%和15.62%(P<0.01)。COX多因素分析显示,肿瘤大小、腋窝淋巴结转移和是否行放射治疗是影响预后的独立因素。结论:对于30岁以下乳腺癌患者,需早期诊断,早期进行正规的综合治疗,以提高无瘤生存率,降低局部复发率。
Objective: To investigate the clinical characteristics of breast cancer under 30 years old, tumor-free survival rate and prognostic factors. Methods: The clinical data of 102 patients with breast cancer under 30 years of age treated in our hospital from December 1989 to December 2000 were retrospectively analyzed. The long-term tumor-free survival rate after radiotherapy was observed. The clinical features of radiotherapy and prognosis were analyzed factor. Results: The 3-year disease-free survival rates of patients with tumor diameters ≤3 cm and> 3 cm were 91.67% and 87.04%, respectively (P <0.01). The 3-year, 5-year, and 5-year disease-free survival rates were 92.11% and 81.58% respectively. The 3-year survival rates of 1 to 3 positive patients were 88.24%, 70.59% and ≥4, respectively Three years, 5-year disease-free survival rates were 84.00%, 40.00%. The 3-year and 5-year disease-free survival rates of radiotherapy group were 94.44% and 90.28%, respectively. The 5-year disease-free survival rates of radiotherapy group were 76.67% and 15.62% respectively (P <0.01). COX multivariate analysis showed that tumor size, axillary lymph node metastasis and whether radiation therapy were independent prognostic factors. Conclusion: For patients under 30 years of age with breast cancer, early diagnosis and early comprehensive formal treatment are needed to improve the tumor-free survival rate and reduce the local recurrence rate.