用高蔗糖饲料喂养雄性ＳＤ大鼠，诱发高胰岛素血症及胰岛素抵抗。实验发现第２周时高糖组血糖明显低于对照组，４周后与对照组相比无明显区别。高糖组血清胰岛素水平从第２周开始升高，４周后升高更为明显（Ｐ＜００１）。饲养２０周时取肝，制备肝细胞膜可溶性胰岛素受体，经胰岛素受体放射配体法测定，发现高糖组与对照组间受体亲和力无明显差别，但高糖组的受体最大特异结合与受体浓度低于对照组（Ｐ＜０．０５），说明高蔗糖膳食可引起雄性ＳＤ大鼠高胰岛素血症，而胰岛素受体结合动力学改变加重胰岛素抵抗 Male SD rats were fed with high sucrose diet to induce hyperinsulinemia and insulin resistance. The experiment found that the second week of high glucose group, blood glucose was significantly lower than the control group after 4 weeks compared with the control group no significant difference. The level of serum insulin in high glucose group increased from the second week and became more obvious after 4 weeks (P <001). Twenty weeks after feeding, the liver was taken to prepare soluble insulin receptor of liver cell membrane. The receptor affinity of the high glucose group and the control group was not significantly different, but the receptor of high glucose group had the highest specific binding And the receptor concentration was lower than the control group (P <0.05), indicating that high sucrose diet can cause hyperinsulinemia in male SD rats, and changes in insulin receptor binding kinetics aggravate insulin resistance