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应用LSAB法对57例乳腺癌的雌激素受体(ER)、孕激素受体(PR)和P_(53)基因表达进行研究,结果:28例ER、PR阳性组中,P_(53)阳性表达6例(20.7％);28例ER、PR阳性组中,P_(53)阳性表达15例(53.6％),两组差异有显著性(P<0.05)。在21例P_(53)表达病例中,15例淋巴结转移,转移率71.4％,在36例P_(53)阴性病例中,8例淋巴结转移,转移率为22.2％,两者比较有显著性差异。提示P_(53)表达与ER、PR存在及腋窝淋巴结转移有关;检测ER、PR和P_(53)可作为临床内分泌治疗的依据;P_(53)的检测可考虑作为乳腺癌预后判断的一个可靠指标。
The LSAB method was used to study the expression of estrogen receptor (ER), progesterone receptor (PR) and P_ (53) genes in 57 cases of breast cancer. Results: Positive P_ (53) in 28 cases of ER, PR positive group Six cases (20.7%) were expressed; in the ER and PR positive group, 15 cases (53.6%) were positive for P_(53). There was a significant difference between the two groups (P<0.05). Of the 21 P_(53) cases, 15 had lymph node metastasis with a metastatic rate of 71.4%. Among the 36 P_(53) negative cases, 8 had lymph node metastases with a metastatic rate of 22.2%. There was a significant difference between them. . It suggested that the expression of P_(53) was related to the presence of ER, PR and axillary lymph node metastasis. Detection of ER, PR and P_(53) could be used as the basis of clinical endocrine therapy. The detection of P_(53) could be considered as a reliable predictor of prognosis of breast cancer. index.