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目的探讨快速检测血浆心肌脂肪酸结合蛋白(H-FABP)在诊断早期急性心肌梗死(AMI)中的价值。方法比较H-FABP、cTnI、CK-MB和MYO四种物质定量检测诊断发病6h内AMI的敏感性、特异性和准确性;比较H-FABP快速检测试剂条定性检测结果与ELISA定量检测结果。结果H-FABP诊断发病3h和6h内AMI的敏感性显著高于cTnI和CK-MB,特异性相比,差异无显著性,诊断准确性显著高于cTnI、CK-MB和MYO。试剂条定性检测结果与ELISA比较符合率达96.9%。结论H-FABP定性检测试剂条可用于早期AMI筛选诊断。
Objective To investigate the value of rapid detection of plasma myocardial fatty acid-binding protein (H-FABP) in the diagnosis of early acute myocardial infarction (AMI). Methods The sensitivity, specificity and accuracy of quantitative detection of AMI in 6 hours after H-FABP, cTnI, CK-MB and MYO were compared. The qualitative and quantitative detection results of H-FABP rapid detection reagent strip and ELISA were compared. Results The sensitivity of AMI in 3h and 6h after H-FABP diagnosis was significantly higher than that of cTnI and CK-MB. There was no significant difference between the two groups in the specificity of H-FABP diagnosis. The diagnostic accuracy was significantly higher than that of cTnI, CK-MB and MYO. The qualitative test results of the reagent strips and ELISA were in line with 96.9%. Conclusion H-FABP qualitative test strips can be used for early diagnosis of AMI screening.