哮喘的发病学涉及许多因素。其中有些,例如伴有通气和灌流异常的肺脏生理学改变,是所有哮喘病人都共有的。另一些因素能导致哮喘的发作。这些因素可能在一些病人中起作用而在另一些病人则无作用。为了使治疗恰当,必须首先确定各个病人中起作用的因素。本文主要讨论导致哮喘发作的因素以及这些因素如何通过“最终共同途径”导致哮喘的发作。 The pathogenesis of asthma involves many factors. Some of them, such as lung physiology with abnormal ventilation and perfusion, are common to all asthmatics. Other factors can lead to asthma attacks. These factors may play a role in some patients but not others. In order to make the treatment appropriate, one must first determine the factors that play a role in each individual patient. This article focuses on the factors that lead to the onset of asthma and how these factors contribute to the onset of asthma through “ultimate commonalities.”